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Refractory Neoplasm

MedGen UID:
233913
•Concept ID:
C1335729
•
Neoplastic Process
Synonym: Refractory Tumor

Definition

A neoplasm that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Neoplasm

Professional guidelines

PubMed

Apoptosis-mediated inhibition of human T-cell acute lymphoblastic leukemia upon treatment with Staphylococus Aureus enterotoxin-superantigen.
Duarte A, Montagna DR, Pastorini M, Alemán M
Front Immunol 2023;14:1176432. Epub 2023 Jun 12 doi: 10.3389/fimmu.2023.1176432. PMID: 37377961Free PMC Article
CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.
Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL, MacDougall JR, Rastelli L, Herrmann J, Gallo M, Gazit-Bornstein G, Senter PD, Meyer DL, Lichenstein HS, LaRochelle WJ
Clin Cancer Res 2006 Feb 15;12(4):1373-82. doi: 10.1158/1078-0432.CCR-05-2018. PMID: 16489096

Recent clinical studies

Etiology

Prognostic significance of VEGF receptors expression on the tumor cells in skull base chordoma.
Morimoto Y, Tamura R, Ohara K, Kosugi K, Oishi Y, Kuranari Y, Yoshida K, Toda M
J Neurooncol 2019 Aug;144(1):65-77. Epub 2019 Jun 25 doi: 10.1007/s11060-019-03221-z. PMID: 31240525
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies.
Ryan DP, Supko JG, Eder JP, Seiden MV, Demetri G, Lynch TJ, Fischman AJ, Davis J, Jimeno J, Clark JW
Clin Cancer Res 2001 Feb;7(2):231-42. PMID: 11234874
Neoplastic meningitis as the presentation of occult primitive neuroectodermal tumors.
Jennings MT, Slatkin N, D'Angelo M, Ketonen L, Johnson MD, Rosenblum M, Creasy J, Tulipan N, Walker R
J Child Neurol 1993 Oct;8(4):306-12. doi: 10.1177/088307389300800403. PMID: 8228025

Diagnosis

CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.
Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL, MacDougall JR, Rastelli L, Herrmann J, Gallo M, Gazit-Bornstein G, Senter PD, Meyer DL, Lichenstein HS, LaRochelle WJ
Clin Cancer Res 2006 Feb 15;12(4):1373-82. doi: 10.1158/1078-0432.CCR-05-2018. PMID: 16489096
Neoplastic meningitis as the presentation of occult primitive neuroectodermal tumors.
Jennings MT, Slatkin N, D'Angelo M, Ketonen L, Johnson MD, Rosenblum M, Creasy J, Tulipan N, Walker R
J Child Neurol 1993 Oct;8(4):306-12. doi: 10.1177/088307389300800403. PMID: 8228025

Therapy

CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.
Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL, MacDougall JR, Rastelli L, Herrmann J, Gallo M, Gazit-Bornstein G, Senter PD, Meyer DL, Lichenstein HS, LaRochelle WJ
Clin Cancer Res 2006 Feb 15;12(4):1373-82. doi: 10.1158/1078-0432.CCR-05-2018. PMID: 16489096
Genistein enhances the cisplatin-induced inhibition of cell growth and apoptosis in human malignant melanoma cells.
Tamura S, Bito T, Ichihashi M, Ueda M
Pigment Cell Res 2003 Oct;16(5):470-6. doi: 10.1034/j.1600-0749.2003.00068.x. PMID: 12950722
No longer a molecular black box--new clues to apoptosis and drug resistance in melanoma.
Satyamoorthy K, Bogenrieder T, Herlyn M
Trends Mol Med 2001 May;7(5):191-4. doi: 10.1016/s1471-4914(01)02013-5. PMID: 11325619
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies.
Ryan DP, Supko JG, Eder JP, Seiden MV, Demetri G, Lynch TJ, Fischman AJ, Davis J, Jimeno J, Clark JW
Clin Cancer Res 2001 Feb;7(2):231-42. PMID: 11234874
Therapy of hepatocellular cancer with combined intrahepatic arterial chemotherapy and whole liver irradiation.
Friedman MA, Volberding PA, Cassidy MJ, Resser KJ, Wasserman TH, Phillips TL
Ann Acad Med Singap 1980 Apr;9(2):260-3. PMID: 6252817

Prognosis

Apoptosis-mediated inhibition of human T-cell acute lymphoblastic leukemia upon treatment with Staphylococus Aureus enterotoxin-superantigen.
Duarte A, Montagna DR, Pastorini M, Alemán M
Front Immunol 2023;14:1176432. Epub 2023 Jun 12 doi: 10.3389/fimmu.2023.1176432. PMID: 37377961Free PMC Article
Prognostic significance of VEGF receptors expression on the tumor cells in skull base chordoma.
Morimoto Y, Tamura R, Ohara K, Kosugi K, Oishi Y, Kuranari Y, Yoshida K, Toda M
J Neurooncol 2019 Aug;144(1):65-77. Epub 2019 Jun 25 doi: 10.1007/s11060-019-03221-z. PMID: 31240525
CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.
Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL, MacDougall JR, Rastelli L, Herrmann J, Gallo M, Gazit-Bornstein G, Senter PD, Meyer DL, Lichenstein HS, LaRochelle WJ
Clin Cancer Res 2006 Feb 15;12(4):1373-82. doi: 10.1158/1078-0432.CCR-05-2018. PMID: 16489096
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies.
Ryan DP, Supko JG, Eder JP, Seiden MV, Demetri G, Lynch TJ, Fischman AJ, Davis J, Jimeno J, Clark JW
Clin Cancer Res 2001 Feb;7(2):231-42. PMID: 11234874

Clinical prediction guides

CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.
Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL, MacDougall JR, Rastelli L, Herrmann J, Gallo M, Gazit-Bornstein G, Senter PD, Meyer DL, Lichenstein HS, LaRochelle WJ
Clin Cancer Res 2006 Feb 15;12(4):1373-82. doi: 10.1158/1078-0432.CCR-05-2018. PMID: 16489096
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies.
Ryan DP, Supko JG, Eder JP, Seiden MV, Demetri G, Lynch TJ, Fischman AJ, Davis J, Jimeno J, Clark JW
Clin Cancer Res 2001 Feb;7(2):231-42. PMID: 11234874

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